Chemical Exchange Saturation Transfer Imaging

Chemical Exchange Saturation Transfer Imaging

Advances and Applications

van Zijl, Peter C.M.; Gilad, Assaf A.; McMahon, Michael T.; Bulte, Jeff W.M.

Pan Stanford Publishing Pte Ltd

01/2017

496

Dura

Inglês

9789814745703

15 a 20 dias

922

Descrição não disponível.
On the discovery of the "saturation transfer" method. Development of Chemical Exchange Saturation Transfer (CEST). History of in vivo Exchange Transfer spectroscopy and imaging at Johns Hopkins University and Kennedy Krieger Institute. Early discover and investigations of paraCEST agents in Dallas. The birth of CEST agents in Torino. General theory of CEST image acquisition and post-processing. Uniform-MT- method to separate CEST contrast from MT effects. hyperCEST imaging. The current landscape of diaCEST imaging agents. The evolution of genetically encoded CEST MRI reporters: opportunities and challenges. paraCEST agents: design, discovery and implementation. Transition metal paraCEST probes: alternatives to lanthanides. Responsive paraCEST MRI contrast agents and their biomedical applications. Saturating compartmentalized water protons: Liposome- and Cell-based CEST agents. Principles and applications of Amide Proton Transfer (APT) imaging. Cartilage and intravertebral disc imaging and the Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) experiment. glucoCEST: imaging glucose in tumors. Creatine Chemical Exchange Saturation Transfer imaging. Iodinated contrast media as pH responsive CEST agents.
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